| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
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| Ligand | BDBM50312869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1717751 (CHEMBL4132751) |
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| Ki | 17000±n/a nM |
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| Citation |  Vettorazzi, M; Angelina, E; Lima, S; Gonec, T; Otevrel, J; Marvanova, P; Padrtova, T; Mokry, P; Bobal, P; Acosta, LM; Palma, A; Cobo, J; Bobalova, J; Csollei, J; Malik, I; Alvarez, S; Spiegel, S; Jampilek, J; Enriz, RD An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors. Eur J Med Chem139:461-481 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 1 |
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| Name: | Sphingosine kinase 1 |
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| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 42521.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYA1 |
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| Residue: | 384 |
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| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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| BDBM50312869 |
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| n/a |
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| Name | BDBM50312869 |
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| Synonyms: | 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CHEMBL1076555 | N-aryl-4-aryl-1,3-thiazole-2-amine, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11ClN2OS |
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| Mol. Mass. | 302.779 |
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| SMILES | Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1 |
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| Structure | 
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