| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 3 |
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| Ligand | BDBM50280394 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1721963 (CHEMBL4136963) |
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| IC50 | 17600±n/a nM |
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| Citation |  Sonawane, YA; Zhu, Y; Garrison, JC; Ezell, EL; Zahid, M; Cheng, X; Natarajan, A Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors. ACS Med Chem Lett8:1183-1187 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 3 |
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| Name: | Rap guanine nucleotide exchange factor 3 |
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| Synonyms: | CGEF1 | EPAC | EPAC 1 | EPAC1 | Exchange factor directly activated by cAMP 1 | Exchange protein directly activated by cAMP 1 | RAPGEF3 | RPGF3_HUMAN | Rap1 guanine-nucleotide-exchange factor directly activated by cAMP | cAMP-GEFI | cAMP-regulated guanine nucleotide exchange factor I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103769.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104531 |
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| Residue: | 923 |
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| Sequence: | MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
FYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD
FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML
HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL
PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL
VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT
ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV
RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE
KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA
YVQQLKVIDNQRELSRLSRELEP
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| BDBM50280394 |
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| n/a |
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| Name | BDBM50280394 |
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| Synonyms: | CHEMBL4168137 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10Br2FNS |
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| Mol. Mass. | 367.075 |
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| SMILES | C[C@@H]1CCc2c(Br)c(F)c(Br)cc2N1C=S |r| |
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| Structure | 
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