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TargetVesicular acetylcholine transporter
LigandBDBM50018078
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1722786 (CHEMBL4137786)
Ki 49±n/a nM
Citation Bautista-Aguilera, ÓM; Budni, J; Mina, F; Medeiros, EB; Deuther-Conrad, W; Entrena, JM; Moraleda, I; Iriepa, I; López-Muñoz, F; Marco-Contelles, J Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. J Med Chem61:6937-6943 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vesicular acetylcholine transporter
Name:Vesicular acetylcholine transporter
Synonyms:Slc18a3 | Solute carrier family 18 member 3 | VACHT_RAT | Vacht | Vat | rVAT
Type:PROTEIN
Mol. Mass.:56533.41
Organism:Rattus norvegicus
Description:ChEMBL_1503353
Residue:530
Sequence:
MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDY
IAHMRGGSEGPTLVSEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESE
DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFA
ARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAG
KRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTT
CNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYG
ALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSV
YAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRS
ERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50018078
n/a
NameBDBM50018078
Synonyms:2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Phenyl-piperidin-1-yl)-cyclohexanol([3H]-(-)Vesamicol) | CHEMBL20943 | US10421722, Compound Vesamicolb | V-100
TypeSmall organic molecule
Emp. Form.C17H25NO
Mol. Mass.259.3865
SMILESOC1CCCCC1N1CCC(CC1)c1ccccc1
Structure
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