| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50016683 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_4270 |
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| IC50 | 100±n/a nM |
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| Citation |  Huang, FC; Shoupe, TS; Lin, CJ; Lee, TD; Chan, WK; Tan, J; Schnapper, M; Suh, JT; Gordon, RJ; Sonnino, PA Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. J Med Chem32:1836-42 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50016683 |
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| n/a |
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| Name | BDBM50016683 |
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| Synonyms: | 2-[4-(3-Chloro-benzyloxy)-phenyl]-N-hydroxy-N-methyl-acetamide | CHEMBL55620 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16ClNO3 |
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| Mol. Mass. | 305.756 |
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| SMILES | CN(O)C(=O)Cc1ccc(OCc2cccc(Cl)c2)cc1 |
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| Structure | 
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