| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal calcium sensor 1 |
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| Ligand | BDBM50288830 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1730087 (CHEMBL4145365) |
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| Kd | 11530±n/a nM |
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| Citation |  Roca, C; Martinez-González, L; Daniel-Mozo, M; Sastre, J; Infantes, L; Mansilla, A; Chaves-Sanjuan, A; González-Rubio, JM; Gil, C; Cañada, FJ; Martinez, A; Sanchez-Barrena, MJ; Campillo, NE Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem61:5910-5921 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal calcium sensor 1 |
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| Name: | Neuronal calcium sensor 1 |
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| Synonyms: | FLUP | FREQ | Frequenin homolog | Frequenin-like protein | Frequenin-like ubiquitous protein | NCS-1 | NCS1 | NCS1_HUMAN | Neuronal calcium sensor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21869.38 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118331 |
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| Residue: | 190 |
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| Sequence: | MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV
QALSLYDGLV
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| BDBM50288830 |
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| n/a |
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| Name | BDBM50288830 |
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| Synonyms: | CHEMBL4177272 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11F3N2O2S |
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| Mol. Mass. | 352.331 |
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| SMILES | COc1ccccc1C(=O)Nc1nc2cc(ccc2s1)C(F)(F)F |
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| Structure | 
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