Ki Summary

Reaction Details

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Target

cGMP-specific 3',5'-cyclic phosphodiesterase

Ligand

BDBM50017101

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_216654 (CHEMBL821135)

IC50

>1000000±n/a nM

Citation

Marivet, MC; Bourguignon, JJ; Lugnier, C; Mann, A; Stoclet, JC; Wermuth, CG Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. J Med Chem32:1450-7 (1989) [PubMed]

More Info.:

Get all data from this article, Assay Method

cGMP-specific 3',5'-cyclic phosphodiesterase

Name:

cGMP-specific 3',5'-cyclic phosphodiesterase

Synonyms:

PDE5 | PDE5A | PDE5A_BOVIN | Phosphodiesterase 5A

Type:

PROTEIN

Mol. Mass.:

98615.45

Organism:

Bos taurus

Description:

ChEMBL_155186

Residue:

865

Sequence:

MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN

BDBM50017101

n/a

Name

BDBM50017101

Synonyms:

7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoindol-3-one | CHEMBL35053

Type

Small organic molecule

Emp. Form.

C14H17NO3

Mol. Mass.

247.2897

SMILES

COc1cc2CC[C@H]3[C@@H](CNC3=O)c2cc1OC

Structure