| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50292543 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1732722 (CHEMBL4148258) |
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| IC50 | 30010±n/a nM |
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| Citation |  Dias Viegas, FP; de Freitas Silva, M; Divino da Rocha, M; Castelli, MR; Riquiel, MM; Machado, RP; Vaz, SM; Simões de Lima, LM; Mancini, KC; Marques de Oliveira, PC; Morais, ÉP; Gontijo, VS; da Silva, FMR; D'Alincourt da Fonseca Peçanha, D; Castro, NG; Neves, GA; Giusti-Paiva, A; Vilela, FC; Orlandi, L; Camps, I; Veloso, MP; Leomil Coelho, LF; Ionta, M; Ferreira-Silva, GÁ; Pereira, RM; Dardenne, LE; Guedes, IA; de Oliveira Carneiro Junior, W; Quaglio Bellozi, PM; Pinheiro de Oliveira, AC; Ferreira, FF; Pruccoli, L; Tarozzi, A; Viegas, C Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. Eur J Med Chem147:48-65 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 71812.79 |
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| Organism: | Electrophorus electricus (Electric eel) |
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| Description: | n/a |
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| Residue: | 633 |
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| Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
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| BDBM50292543 |
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| n/a |
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| Name | BDBM50292543 |
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| Synonyms: | CHEMBL4174008 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3O2 |
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| Mol. Mass. | 337.4155 |
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| SMILES | OC1CCCN(Cc2ccc(cc2)C(=O)N\N=C\c2ccccc2)C1 |
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| Structure | 
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