| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 |
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| Ligand | BDBM350280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1733858 (CHEMBL4149394) |
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| IC50 | 4.1±n/a nM |
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| Citation |  Joharapurkar, AA; Pandya, VB; Patel, VJ; Desai, RC; Jain, MR Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases. J Med Chem61:6964-6982 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Egl nine homolog 1 |
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| Name: | Egl nine homolog 1 |
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| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
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| Type: | Protein |
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| Mol. Mass.: | 46035.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9GZT9 |
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| Residue: | 426 |
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| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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| BDBM350280 |
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| n/a |
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| Name | BDBM350280 |
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| Synonyms: | 2-(4-Hydroxy-2-oxo-1-(3'- (trifluoromethoxy)-[1,1'- biphenyl]-4-yl)-1,2,5,7- tetrahydrothieno[3,4-b] pyridine-3-arboxamido) acetic acid | US10208060, Example 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17F3N2O6S |
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| Mol. Mass. | 506.451 |
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| SMILES | OC(=O)CNC(=O)c1c(O)c2CSCc2n(-c2ccc(cc2)-c2cccc(OC(F)(F)F)c2)c1=O |
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| Structure | 
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