| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN3 |
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| Ligand | BDBM50385806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1733869 (CHEMBL4149405) |
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| IC50 | 1.6±n/a nM |
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| Citation |  Joharapurkar, AA; Pandya, VB; Patel, VJ; Desai, RC; Jain, MR Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases. J Med Chem61:6964-6982 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN3 |
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| Name: | Prolyl hydroxylase EGLN3 |
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| Synonyms: | EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3) |
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| Type: | Protein |
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| Mol. Mass.: | 27265.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H6Z9 |
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| Residue: | 239 |
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| Sequence: | MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
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| BDBM50385806 |
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| n/a |
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| Name | BDBM50385806 |
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| Synonyms: | CHEMBL2041193 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30N6O4 |
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| Mol. Mass. | 562.6184 |
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| SMILES | Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ccncn1 |
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| Structure | 
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