| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN2 |
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| Ligand | BDBM240926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1733849 (CHEMBL4149385) |
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| IC50 | 240±n/a nM |
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| Citation |  Joharapurkar, AA; Pandya, VB; Patel, VJ; Desai, RC; Jain, MR Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases. J Med Chem61:6964-6982 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN2 |
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| Name: | Prolyl hydroxylase EGLN2 |
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| Synonyms: | EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1) |
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| Type: | Protein |
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| Mol. Mass.: | 43657.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96KS0 |
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| Residue: | 407 |
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| Sequence: | MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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| BDBM240926 |
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| n/a |
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| Name | BDBM240926 |
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| Synonyms: | US9409892, 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N3O6 |
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| Mol. Mass. | 435.4293 |
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| SMILES | COc1ccc(Oc2ccc3c(O)c(nc(C#N)c3c2)C(=O)NC(C)(C)CC(O)=O)cc1 |
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| Structure | 
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