Reaction Details |
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Target | Excitatory amino acid transporter 1 |
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Ligand | BDBM50093753 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1735430 (CHEMBL4150966) |
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IC50 | 2089±n/a nM |
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Citation | Fu, H; Zhang, J; Tepper, PG; Bunch, L; Jensen, AA; Poelarends, GJ Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. J Med Chem61:7741-7753 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Excitatory amino acid transporter 1 |
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Name: | Excitatory amino acid transporter 1 |
Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59577.19 |
Organism: | Homo sapiens (Human) |
Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
Residue: | 542 |
Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
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BDBM50093753 |
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n/a |
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Name | BDBM50093753 |
Synonyms: | (2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S)-2-amino-3-(benzyloxy)succinic acid | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID | CHEMBL79140 | DL-TBOA |
Type | Small organic molecule |
Emp. Form. | C11H13NO5 |
Mol. Mass. | 239.2246 |
SMILES | N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| |
Structure |
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