| Reaction Details |
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 | Report a problem with these data |
| Target | Pancreatic triacylglycerol lipase |
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| Ligand | BDBM50367211 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1735716 (CHEMBL4151252) |
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| IC50 | 850±n/a nM |
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| Citation |  Jalaja, R; Leela, SG; Valmiki, PK; Salfeena, CTF; Ashitha, KT; Krishna Rao, VRD; Nair, MS; Gopalan, RK; Somappa, SB Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors. ACS Med Chem Lett9:662-666 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pancreatic triacylglycerol lipase |
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| Name: | Pancreatic triacylglycerol lipase |
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| Synonyms: | LIPP_PIG | PL | PNLIP | PTL | Pancreatic lipase | Pancreatic triacylglycerol lipase |
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| Type: | Enzyme |
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| Mol. Mass.: | 50080.69 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P00591 |
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| Residue: | 450 |
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| Sequence: | SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTI
TNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQ
NIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAE
PCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQK
NILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPC
PSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSL
FGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASK
ITVERNDGKVYDFCSQETVREEVLLTLNPC
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| BDBM50367211 |
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| n/a |
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| Name | BDBM50367211 |
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| Synonyms: | CHEMBL4165339 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N4O5 |
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| Mol. Mass. | 534.6465 |
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| SMILES | [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(cc4)[N+]([O-])=O)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| |
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| Structure | 
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