Reaction Details |
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Target | Carbonic anhydrase 2 |
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Ligand | BDBM50369875 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1737218 (CHEMBL4152968) |
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Ki | 6.8±n/a nM |
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Citation | Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN 2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. Eur J Med Chem151:363-375 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 2 |
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Name: | Carbonic anhydrase 2 |
Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
Type: | Enzyme |
Mol. Mass.: | 29250.71 |
Organism: | Homo sapiens (Human) |
Description: | P00918 |
Residue: | 260 |
Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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BDBM50369875 |
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n/a |
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Name | BDBM50369875 |
Synonyms: | CHEMBL4171554 |
Type | Small organic molecule |
Emp. Form. | C26H27N3O4S |
Mol. Mass. | 477.575 |
SMILES | NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@@H]1Cc1ccccc1)C(=O)Cc1ccccc1 |r| |
Structure |
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