Reaction Details |
| Report a problem with these data |
Target | Muscarinic acetylcholine receptor M2 |
---|
Ligand | BDBM50018056 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_140037 |
---|
IC50 | 140±n/a nM |
---|
Citation | Engel, WW; Eberlein, WG; Mihm, G; Hammer, R; Trummlitz, G Tricyclic compounds as selective muscarinic receptor antagonists. 3. Structure-selectivity relationships in a series of cardioselective (M2) antimuscarinics. J Med Chem32:1718-24 (1989) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Muscarinic acetylcholine receptor M2 |
---|
Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51555.53 |
Organism: | RAT |
Description: | P10980 |
Residue: | 466 |
Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
BDBM50018056 |
---|
n/a |
---|
Name | BDBM50018056 |
Synonyms: | (AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one | 11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one | 2-Diethylaminomethyl-1-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperidinium | 5-{2-[2-(2-Dipropylamino-ethyl)-piperidin-1-yl]-acetyl}-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one | AF-DX 116 | AF-DX 116,(+/-) | CHEMBL17045 | Otenzepad |
Type | Small organic molecule |
Emp. Form. | C24H31N5O2 |
Mol. Mass. | 421.5352 |
SMILES | CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12 |
Structure |
|