| Reaction Details |
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 | Report a problem with these data |
| Target | Myosin-4 |
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| Ligand | BDBM50449475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739757 (CHEMBL4155507) |
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| IC50 | 400±n/a nM |
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| Citation |  Roman, BI; Verhasselt, S; Stevens, CV Medicinal Chemistry and Use of Myosin II Inhibitor ( S)-Blebbistatin and Its Derivatives. J Med Chem61:9410-9428 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myosin-4 |
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| Name: | Myosin-4 |
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| Synonyms: | MYH4 | MYH4_RABIT | MyHC-2b | Myosin heavy chain 2b | Myosin heavy chain 4 | Myosin heavy chain, skeletal muscle, juvenile |
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| Type: | PROTEIN |
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| Mol. Mass.: | 222846.65 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | ChEMBL_118082 |
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| Residue: | 1938 |
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| Sequence: | MSSDADMAIFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVADPKESFVKATVQSREGGKV
TAKTEAGATVTVKEDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSG
LFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE
SGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVR
NDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDL
IEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFTSDERVSIYKLTGAVM
HYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTV
QQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLVHYAGTVDYNITGWLDKN
KDPLNETVVGLYQKSAMKTLAFLFTGTAAAEAEGGGKKGGKKKGSSFQTVSALFRENLNK
LMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD
FKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGLLEEMR
DDKLAQLITRTQAMCRGFLARVEYKKMVERRESIFCIQYNIRAFMNVKHWPWMKLYFKIK
PLLKSAETEKEMANMKEEFEKTKESLAKAEAKRKELEEKMVALMQEKNDLQLQVQAEADS
LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL
ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV
NTLTKAKTKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD
EKLKKKEFEMSNLQSKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS
DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA
DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRTLEDQVS
ELKTKEEEHQRLINDLSAQRARLQTESGEFSRQLDEKDSLVSQLSRGKQAFTQQIEELKR
QLEEEIKAKSALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET
DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA
ACAALDKKQRNFDKILAEWKHKYEETHAELEASQKESRSLSTELFKVKNAYEESLDQLET
LKRENKNLQQEISDLTEQIAEGGKRIHELEKVKKQVEQEKSELQAALEEAEASLEHEEGK
ILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKK
MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERR
ANLLQAEIEELRATLEQTERSRKVAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI
QGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRL
DEAEQLALKGGKKQIQKLEARVRELEAEVESEQKRNVEAVKGLRKHERRVKELTYQTEED
RKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRKLQHELEEAEERADIAESQV
NKLRVKSREVHTKVISEE
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| BDBM50449475 |
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| n/a |
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| Name | BDBM50449475 |
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| Synonyms: | CHEMBL4162111 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15N3O4 |
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| Mol. Mass. | 337.3294 |
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| SMILES | Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccc(cc1)[N+]([O-])=O |r,t:5| |
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| Structure | 
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