Reaction Details |
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Target | Cruzipain |
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Ligand | BDBM50451631 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1745981 (CHEMBL4180491) |
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Ki | 1.6±n/a nM |
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Citation | Silva, DG; Ribeiro, JFR; De Vita, D; Cianni, L; Franco, CH; Freitas-Junior, LH; Moraes, CB; Rocha, JR; Burtoloso, ACB; Kenny, PW; Leitão, A; Montanari, CA A comparative study of warheads for design of cysteine protease inhibitors. Bioorg Med Chem Lett27:5031-5035 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cruzipain |
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Name: | Cruzipain |
Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
Type: | Protein |
Mol. Mass.: | 49831.41 |
Organism: | Trypanosoma cruzi |
Description: | P25779 |
Residue: | 467 |
Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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BDBM50451631 |
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n/a |
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Name | BDBM50451631 |
Synonyms: | CHEMBL4212454 |
Type | Small organic molecule |
Emp. Form. | C21H28N6O2 |
Mol. Mass. | 396.486 |
SMILES | CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc(nn1C)C(C)(C)C |r| |
Structure |
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