| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50019553 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157760 (CHEMBL768679) |
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| IC50 | 39300±n/a nM |
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| Citation |  Kees, KL; Musser, JH; Chang, J; Skowronek, M; Lewis, AJ Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors. J Med Chem29:2329-34 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50019553 |
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| n/a |
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| Name | BDBM50019553 |
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| Synonyms: | 4-[3-(4-Acetyl-3-hydroxy-phenoxymethyl)-phenylcarbamoyl]-butyric acid methyl ester | CHEMBL307575 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23NO6 |
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| Mol. Mass. | 385.4104 |
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| SMILES | COC(=O)CCCC(=O)Nc1cccc(COc2ccc(C(C)=O)c(O)c2)c1 |
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| Structure | 
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