| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50452614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1747982 (CHEMBL4182492) |
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| IC50 | 502±n/a nM |
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| Citation |  Hagimori, M; Temma, T; Kudo, S; Sano, K; Kondo, N; Mukai, T Synthesis of radioiodinated probes targeted toward matrix metalloproteinase-12. Bioorg Med Chem Lett28:193-195 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50452614 |
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| n/a |
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| Name | BDBM50452614 |
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| Synonyms: | CHEMBL4214104 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21IN2O6S |
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| Mol. Mass. | 592.403 |
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| SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)c3ccc(I)cc3)cc21)C(O)=O |r| |
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| Structure | 
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