| Reaction Details |
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 | Report a problem with these data |
| Target | EH domain-containing protein 1 |
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| Ligand | BDBM50453867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1751402 (CHEMBL4186162) |
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| IC50 | 62800±n/a nM |
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| Citation |  Kamens, AJ; Mientkiewicz, KM; Eisert, RJ; Walz, JA; Mace, CR; Kritzer, JA Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorg Med Chem26:1206-1211 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| EH domain-containing protein 1 |
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| Name: | EH domain-containing protein 1 |
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| Synonyms: | EH domain-containing protein 1 | EHD1 | EHD1_HUMAN | PAST | PAST homolog 1 | PAST1 | Testilin | hPAST1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60628.64 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118187 |
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| Residue: | 534 |
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| Sequence: | MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPM
VLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRR
PFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAE
RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSL
GKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKR
ARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQ
ELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNG
PFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTV
LGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
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| BDBM50453867 |
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| n/a |
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| Name | BDBM50453867 |
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| Synonyms: | CHEMBL4205818 |
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| Type | Small organic molecule |
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| Emp. Form. | C55H67N9O14S2 |
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| Mol. Mass. | 1142.302 |
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| SMILES | NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSCc2ccccc2CSCCNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O)NC(=O)CCC#C |r| |
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| Structure | 
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