| Reaction Details |
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 | Report a problem with these data |
| Target | Sensor protein kinase WalK |
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| Ligand | BDBM50453879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1751444 (CHEMBL4186204) |
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| IC50 | 212000±n/a nM |
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| Citation |  Vo, CD; Shebert, HL; Zikovich, S; Dryer, RA; Huang, TP; Moran, LJ; Cho, J; Wassarman, DR; Falahee, BE; Young, PD; Gu, GH; Heinl, JF; Hammond, JW; Jackvony, TN; Frederick, TE; Blair, JA Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. Bioorg Med Chem Lett27:5235-5244 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sensor protein kinase WalK |
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| Name: | Sensor protein kinase WalK |
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| Synonyms: | 2.7.13.3 | Phosphate regulon sensor protein phoR |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63912.81 |
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| Organism: | Staphylococcus aureus subsp. aureus CN1 |
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| Description: | ChEMBL_117873 |
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| Residue: | 554 |
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| Sequence: | MMKFHHRLMLLISSILIISFVTLGIIIHASITYVLSEKHEQALATDARSYIYLVQDNEID
KVKEIVKQQNIDLLITKHDKKVFSSGKLKAIPNSDSYIQKRDVFIFNKKVNGYHVWIKGY
NNDITEMHWTLWKYLILTCLVVLICLYFASRSFKRTLIRPIQEVTYATQLLANGYYHIRV
PESNVVETKALFVSTNDLARRLQKLNNEQKIQSNRLKTTIENIPSAILMIDRNGKIVVAN
KAYYEQFNISHNIEQVGYHGYVNTEIEQLILESFKVEKPIYEQLEVAINQVHAKYFDISC
VPILTRSQKSLQGILVVMHDITNLKQLENLRREFVANVSHELKTPITSIKGFAETLIDGA
KNDAESLDMFLNIILKESNRIESLVTDLLDLSHIEQHTELDTDYMNLSDLTRRIIDNMMT
QANQKNISIHTDIEKDVIVKAQESKIAQVITNLLTNAINYSYEDGDINVRVYRDDFRVIF
EVQDFGIGIKLEDQQRIFERFYRVDKARSRDSGGTGLGLSITKHIVEAHQGNIEVNSQVG
KGSTFKVILKDYKE
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| BDBM50453879 |
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| n/a |
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| Name | BDBM50453879 |
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| Synonyms: | CHEMBL4202687 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21FO |
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| Mol. Mass. | 272.3571 |
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| SMILES | CCC(C(CC)c1ccc(F)cc1)c1ccc(O)cc1 |
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| Structure | 
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