| Reaction Details |
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 | Report a problem with these data |
| Target | Histidine kinase |
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| Ligand | BDBM50453881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1751472 (CHEMBL4186232) |
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| IC50 | 28000±n/a nM |
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| Citation |  Vo, CD; Shebert, HL; Zikovich, S; Dryer, RA; Huang, TP; Moran, LJ; Cho, J; Wassarman, DR; Falahee, BE; Young, PD; Gu, GH; Heinl, JF; Hammond, JW; Jackvony, TN; Frederick, TE; Blair, JA Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. Bioorg Med Chem Lett27:5235-5244 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histidine kinase |
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| Name: | Histidine kinase |
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| Synonyms: | Cell cycle histidine kinase CckA | cckA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73062.72 |
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| Organism: | Caulobacter vibrioides |
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| Description: | ChEMBL_117872 |
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| Residue: | 691 |
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| Sequence: | MADLQLQDKVSTGAPRRRFDPWLVGAAVFFVAAAALSAAPALKAGPTTLAGLLLLLGVAG
VAVLGLVAIRGSALSGGDADQAEGFIEALAEPAALAAADGRVLAANGPWREVMGEQRRLP
KGVAGSSLFAALVQARQGQMAEGMLSAGGTDYTAKVSRLAGGRLMIRLAPIVVAEPVVED
ASPAPVAERAAPPPSSLDAFAGASPFGAALLEGLEPFTSRVLETNPALTTMTGAKAGVLF
GDLIDAASRAEAETRLNEGRAGPYEVRLARDPSRIAHLYLYRAEGRLVAYMIDVSEQKQI
ELQLSQAQKMQAIGQLAGGVAHDFNNLLTAIQLRLDELLHRHPVGDPSYEGLNEIRQTGV
RAADLVRKLLAFSRKQTVQREVLDLGELISEFEVLLRRLLREDVKLITDYGRDLPQVRAD
KSQLETAVMNLAVNARDAVRAAKGGGVVRIRTARLTRDEAIQLGFPAADGDTAFIEVSDD
GPGIPPDVMGKIFDPFFTTKPVGEGTGLGLATVYGIVKQSDGWIHVHSRPNEGAAFRIFL
PVYEAPAGAVAVQAVAEPAKPRAARDLSGAGRILFVEDEDAVRSVAARLLRARGYEVLEA
ADGEEALIIAEENAGTIDLLISDVIMPGIDGPTLLKKARGYLGTAPVMFISGYAEAEFSD
LLEGETGVTFLPKPIDIKTLAERVKQQLQAA
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| BDBM50453881 |
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| n/a |
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| Name | BDBM50453881 |
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| Synonyms: | CCT018159 | CHEBI:41656 | CHEMBL399530 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N2O4 |
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| Mol. Mass. | 352.3838 |
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| SMILES | CCc1cc(-c2[nH]nc(C)c2-c2ccc3OCCOc3c2)c(O)cc1O |
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| Structure | 
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