| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
|---|
| Ligand | BDBM50453919 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1751566 (CHEMBL4186326) |
|---|
| Ki | 27±n/a nM |
|---|
| Citation |  Hankosky, ER; Joolakanti, SR; Nickell, JR; Janganati, V; Dwoskin, LP; Crooks, PA Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [ Bioorg Med Chem Lett27:5467-5472 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Synaptic vesicular amine transporter |
|---|
| Name: | Synaptic vesicular amine transporter |
|---|
| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55689.58 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q01827 |
|---|
| Residue: | 515 |
|---|
| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
|
|
|
|---|
| BDBM50453919 |
|---|
| n/a |
|---|
| Name | BDBM50453919 |
|---|
| Synonyms: | CHEMBL4204715 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H30ClF2NO |
|---|
| Mol. Mass. | 409.94 |
|---|
| SMILES | Cl.FCCOc1ccccc1CCC1CCN(CCc2ccc(F)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
