| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM50453990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1751735 (CHEMBL4186495) |
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| IC50 | 11000±n/a nM |
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| Citation |  Pandit, SS; Kulkarni, MR; Pandit, YB; Lad, NP; Khedkar, VM Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-? production. Bioorg Med Chem Lett28:24-30 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM50453990 |
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| n/a |
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| Name | BDBM50453990 |
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| Synonyms: | CHEMBL4209097 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F3N7O2S |
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| Mol. Mass. | 489.474 |
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| SMILES | FC(F)(F)c1cncc(c1)-c1ccc2ncc(n2n1)S(=O)(=O)N1CCN(CC1)c1ccccn1 |
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| Structure | 
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