| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM50457006 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758582 (CHEMBL4193590) |
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| Ki | 4306±n/a nM |
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| Citation |  Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. Eur J Med Chem139:250-262 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35037.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22748 |
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| Residue: | 312 |
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| Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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| BDBM50457006 |
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| n/a |
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| Name | BDBM50457006 |
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| Synonyms: | CHEMBL4211148 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17ClN4O4S2 |
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| Mol. Mass. | 524.999 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)N(Cc2ccccc2)c2ccc(Cl)cc12 |
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| Structure | 
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