Reaction Details |
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Target | Tyrosine--tRNA ligase |
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Ligand | BDBM50458118 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1762362 (CHEMBL4197609) |
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Ki | 30±n/a nM |
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Citation | Zhang, B; De Graef, S; Nautiyal, M; Pang, L; Gadakh, B; Froeyen, M; Van Mellaert, L; Strelkov, SV; Weeks, SD; Van Aerschot, A Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases. Eur J Med Chem148:384-396 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine--tRNA ligase |
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Name: | Tyrosine--tRNA ligase |
Synonyms: | 6.1.1.1 | SYY_ECOLI | TyrRS | Tyrosine--tRNA ligase | Tyrosyl-tRNA synthetase | tyrS |
Type: | PROTEIN |
Mol. Mass.: | 47522.37 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_117817 |
Residue: | 424 |
Sequence: | MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKR
FQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENS
AIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQG
YDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTE
GGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQ
YVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLM
QALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCL
ICWK
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BDBM50458118 |
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n/a |
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Name | BDBM50458118 |
Synonyms: | CHEMBL4208126 |
Type | Small organic molecule |
Emp. Form. | C20H24N6O8S |
Mol. Mass. | 508.505 |
SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nccc12 |r| |
Structure |
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