Reaction Details |
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Target | Serine--tRNA ligase |
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Ligand | BDBM50339906 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1762365 (CHEMBL4197612) |
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Ki | 0.180000±n/a nM |
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Citation | Zhang, B; De Graef, S; Nautiyal, M; Pang, L; Gadakh, B; Froeyen, M; Van Mellaert, L; Strelkov, SV; Weeks, SD; Van Aerschot, A Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases. Eur J Med Chem148:384-396 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine--tRNA ligase |
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Name: | Serine--tRNA ligase |
Synonyms: | 6.1.1.11 | SYS_ECOLI | SerRS | Serine--tRNA ligase | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase | serS |
Type: | PROTEIN |
Mol. Mass.: | 48404.41 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_117814 |
Residue: | 430 |
Sequence: | MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQ
AKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDN
VEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFM
LDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
SMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCS
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLR
PYMNGLEYIG
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BDBM50339906 |
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n/a |
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Name | BDBM50339906 |
Synonyms: | ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl(S)-2-amino-3-hydroxypropanoylsulfamate | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE | CHEMBL1163070 | SerSA |
Type | Small organic molecule |
Emp. Form. | C13H19N7O8S |
Mol. Mass. | 433.397 |
SMILES | N[C@@H](CO)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| |
Structure |
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