| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine--tRNA ligase |
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| Ligand | BDBM50458121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1762362 (CHEMBL4197609) |
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| Ki | 2.9±n/a nM |
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| Citation |  Zhang, B; De Graef, S; Nautiyal, M; Pang, L; Gadakh, B; Froeyen, M; Van Mellaert, L; Strelkov, SV; Weeks, SD; Van Aerschot, A Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases. Eur J Med Chem148:384-396 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine--tRNA ligase |
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| Name: | Tyrosine--tRNA ligase |
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| Synonyms: | 6.1.1.1 | SYY_ECOLI | TyrRS | Tyrosine--tRNA ligase | Tyrosyl-tRNA synthetase | tyrS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47522.37 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_117817 |
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| Residue: | 424 |
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| Sequence: | MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKR
FQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENS
AIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQG
YDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTE
GGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQ
YVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLM
QALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCL
ICWK
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| BDBM50458121 |
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| n/a |
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| Name | BDBM50458121 |
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| Synonyms: | CHEMBL1163085 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N7O8S |
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| Mol. Mass. | 509.493 |
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| SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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