Reaction Details |
| Report a problem with these data |
Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
Ligand | BDBM50458499 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1763666 (CHEMBL4198913) |
---|
IC50 | 13±n/a nM |
---|
Citation | Rabal, O; Sánchez-Arias, JA; Cuadrado-Tejedor, M; de Miguel, I; Pérez-González, M; García-Barroso, C; Ugarte, A; Estella-Hermoso de Mendoza, A; Sáez, E; Espelosin, M; Ursua, S; Haizhong, T; Wei, W; Musheng, X; Garcia-Osta, A; Oyarzabal, J Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem150:506-524 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
Type: | Protein |
Mol. Mass.: | 99975.83 |
Organism: | Homo sapiens (Human) |
Description: | O76074 |
Residue: | 875 |
Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
|
|
|
BDBM50458499 |
---|
n/a |
---|
Name | BDBM50458499 |
Synonyms: | CHEMBL4213615 |
Type | Small organic molecule |
Emp. Form. | C25H27N5O4 |
Mol. Mass. | 461.513 |
SMILES | CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(Cc2ccc(cc2)C(=O)NO)ccc1OCC |
Structure |
|