| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM81818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1765385 (CHEMBL4200632) |
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| Ki | 9308±n/a nM |
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| Citation |  Buckley, BJ; Aboelela, A; Minaei, E; Jiang, LX; Xu, Z; Ali, U; Fildes, K; Cheung, CY; Cook, SM; Johnson, DC; Bachovchin, DA; Cook, GM; Apte, M; Huang, M; Ranson, M; Kelso, MJ 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J Med Chem61:8299-8320 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | Plau | UROK_MOUSE | Urokinase-type plasminogen activator (uPA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48282.52 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P06869 |
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| Residue: | 433 |
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| Sequence: | MKVWLASLFLCALVVKNSEGGSVLGAPDESNCGCQNGGVCVSYKYFSRIRRCSCPRKFQG
EHCEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQKPYNAHRPDAISLGLGKH
NYCRNPDNQKRPWCYVQIGLRQFVQECMVHDCSLSKKPSSSVDQQGFQCGQKALRPRFKI
VGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFIQLPKKENYVVY
LGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLKIRTSTGQCAQPSRSIQTI
CLPPRFTDAPFGSDCEITGFGKESESDYLYPKNLKMSVVKLVSHEQCMQPHYYGSEINYK
MLCAADPEWKTDSCKGDSGGPLICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDW
IQSHIGEEKGLAF
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| BDBM81818 |
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| n/a |
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| Name | BDBM81818 |
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| Synonyms: | CAS_1794 | CHEMBL1909810 | HMA | NSC_1794 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18ClN7O |
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| Mol. Mass. | 311.771 |
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| SMILES | NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1 |
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| Structure | 
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