| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-6 |
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| Ligand | BDBM50459526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1766580 (CHEMBL4201827) |
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| IC50 | 1200±n/a nM |
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| Citation |  De Vita, E; Schüler, P; Lovell, S; Lohbeck, J; Kullmann, S; Rabinovich, E; Sananes, A; Heßling, B; Hamon, V; Papo, N; Hess, J; Tate, EW; Gunkel, N; Miller, AK Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity. J Med Chem61:8859-8874 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-6 |
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| Name: | Kallikrein-6 |
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| Synonyms: | KLK6 | KLK6_HUMAN | Kallikrein 6 | PRSS18 | PRSS9 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26861.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_826901 |
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| Residue: | 244 |
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| Sequence: | MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTA
AHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSE
LIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNM
LCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKT
IQAK
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| BDBM50459526 |
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| n/a |
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| Name | BDBM50459526 |
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| Synonyms: | CHEMBL4218619 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N7O2 |
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| Mol. Mass. | 457.5276 |
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| SMILES | Cc1nn(c(C)c1NC(=O)CNC(=O)Cc1c(C)[nH]c2cc(ccc12)C(N)=N)-c1ccccc1 |
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| Structure | 
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