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TargetReverse transcriptase
LigandBDBM50459811
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1767095 (CHEMBL4202342)
IC50 20200±n/a nM
Citation Alexandre, FRRahali, RRahali, HGuillon, SConvard, TFillgrove, KLai, MTMeillon, JCXu, MSmall, JDousson, CBRaheem, IT Synthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4'-Ethynyl-2-fluoro-2'-deoxyadenosine). J Med Chem61:9218-9228 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase
Name:Reverse transcriptase
Synonyms:n/a
Type:Protein
Mol. Mass.:29598.37
Organism:Human immunodeficiency virus 1
Description:Q9WKE8
Residue:254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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  Blast E-value cutoff:
BDBM50459811
n/a
NameBDBM50459811
Synonyms:CHEMBL4206712
TypeSmall organic molecule
Emp. Form.C13H17ClN5O11P3
Mol. Mass.547.675
SMILESNc1nc(Cl)nc2n(cnc12)C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)(C1)C#C
Structure
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