Reaction Details | |||
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Target | Orotidine 5'-phosphate decarboxylase | ||
Ligand | BDBM47402 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1768164 (CHEMBL4220276) | ||
Ki | 11000±n/a nM | ||
Citation | Slusarczyk, M; Ferla, S; Brancale, A; McGuigan, C Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides. Bioorg Med Chem26:551-565 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Orotidine 5'-phosphate decarboxylase | |||
Name: | Orotidine 5'-phosphate decarboxylase | ||
Synonyms: | OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF | ||
Type: | Enzyme | ||
Mol. Mass.: | 24909.45 | ||
Organism: | Methanobacterium thermoautotrophicum | ||
Description: | n/a | ||
Residue: | 228 | ||
Sequence: |
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BDBM47402 | |||
n/a | |||
Name | BDBM47402 | ||
Synonyms: | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,2,4-triazine-3,5-dione | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1,2,4-triazine-3,5-quinone | 2-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione | 6-AZAURIDINE | MLS000028524 | SMR000058273 | cid_5901 | ||
Type | Small organic molecule | ||
Emp. Form. | C8H11N3O6 | ||
Mol. Mass. | 245.1894 | ||
SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O | ||
Structure |