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TargetNeuropeptide Y receptor type 2
LigandBDBM50460002
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1768173 (CHEMBL4220285)
IC50 13±n/a nM
Citation Niida, AKanematsu-Yamaki, YAsakawa, TIshimura, YFujita, HMatsumiya, KNishizawa, NAdachi, YMochida, TTsuchimori, KYoneyama-Hirozane, MSakamoto, JHirabayashi, HFukui, HTakekawa, SAsami, T Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives. Bioorg Med Chem26:566-572 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuropeptide Y receptor type 2
Name:Neuropeptide Y receptor type 2
Synonyms:NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:Enzyme Catalytic Domain
Mol. Mass.:42734.65
Organism:Homo sapiens (Human)
Description:NPY-Y2 NPY2R HUMAN::P49146
Residue:381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50460002
n/a
NameBDBM50460002
Synonyms:CHEMBL4225372
TypeSmall organic molecule
Emp. Form.C128H221N29O32
Mol. Mass.2678.2994
SMILESCC[C@](C)(NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@H](CO)NC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)CC[C@H](NC(=O)[C@H]1CC[C@H](CNC(=O)CCCCCCCCCCCCCCCCCCC(O)=O)CC1)C(O)=O)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1CCCCC1)C(N)=O |r,wU:108.112,125.129,147.151,167.171,2.1,15.16,9.9,97.100,52.53,45.45,wD:117.121,140.147,141.146,158.162,178.182,7.6,86.88,49.49,(20.95,-22.66,;19.72,-23.6,;19.92,-25.13,;21.15,-24.18,;18.39,-25.31,;17.47,-24.08,;15.94,-24.26,;18.09,-22.67,;19.59,-22.33,;19.73,-20.8,;21.06,-20.01,;18.31,-20.19,;17.3,-21.35,;15.78,-21.2,;14.89,-22.46,;15.13,-19.8,;16.02,-18.55,;17.56,-18.69,;13.6,-19.67,;13.56,-18.13,;14.88,-17.33,;12.2,-17.39,;12.17,-15.84,;10.81,-15.1,;10.78,-13.55,;12.1,-12.75,;9.42,-12.81,;9.39,-11.26,;8.03,-10.52,;8,-8.97,;6.64,-8.22,;6.61,-6.67,;5.25,-5.93,;5.22,-4.38,;6.54,-3.59,;7.89,-4.34,;9.22,-3.54,;10.56,-4.3,;11.89,-3.5,;13.25,-4.26,;14.57,-3.46,;15.92,-4.22,;15.94,-5.77,;17.25,-3.42,;18.6,-4.18,;19.93,-3.38,;21.28,-4.14,;22.61,-3.34,;22.59,-1.8,;23.97,-4.1,;23.99,-5.65,;25.35,-6.4,;26.66,-5.6,;28.01,-6.34,;29.33,-5.54,;30.68,-6.28,;30.73,-7.85,;32.02,-5.5,;33.37,-6.24,;34.69,-5.44,;36.03,-6.17,;37.35,-5.39,;38.7,-6.11,;40.03,-5.32,;41.38,-6.07,;42.71,-5.27,;44.06,-6,;45.39,-5.21,;46.72,-5.95,;48.05,-5.15,;49.4,-5.89,;50.72,-5.09,;52.08,-5.81,;53.4,-5.02,;54.74,-5.76,;56.07,-4.96,;57.41,-5.69,;56.03,-3.41,;26.64,-4.06,;25.3,-3.3,;19.91,-1.84,;21.24,-1.04,;18.56,-1.08,;20.84,-26.37,;20.23,-27.79,;22.37,-26.21,;23.28,-27.44,;22.67,-28.85,;23.59,-30.09,;22.96,-31.5,;23.88,-32.73,;25.41,-32.57,;26.03,-31.15,;25.11,-29.91,;24.82,-27.27,;25.43,-25.85,;25.73,-28.5,;27.26,-28.33,;27.88,-26.92,;29.4,-26.75,;30.31,-27.99,;31.85,-27.81,;32.46,-26.41,;31.55,-25.17,;30.01,-25.33,;28.18,-29.57,;27.57,-30.98,;29.7,-29.39,;30.61,-30.63,;32.15,-30.47,;33.06,-31.71,;34.59,-31.55,;32.43,-33.12,;33.97,-32.94,;30,-32.05,;28.47,-32.22,;30.91,-33.28,;30.3,-34.7,;28.76,-34.87,;28.15,-36.28,;26.62,-36.45,;29.06,-37.52,;31.21,-35.94,;30.59,-37.35,;32.73,-35.77,;33.65,-37.01,;35.18,-36.84,;35.79,-35.43,;37.32,-35.26,;37.94,-33.84,;39.47,-33.67,;33.03,-38.42,;31.5,-38.58,;33.94,-39.66,;33.33,-41.06,;32.1,-42,;31.9,-40.47,;34.24,-42.31,;33.62,-43.72,;35.77,-42.14,;36.68,-43.38,;36.07,-44.79,;34.53,-44.96,;36.97,-46.04,;38.21,-43.21,;38.83,-41.8,;39.12,-44.46,;40.65,-44.29,;41.27,-42.88,;42.8,-42.72,;43.43,-41.31,;44.96,-41.14,;45.58,-39.74,;47.11,-39.57,;44.67,-38.49,;41.56,-45.53,;40.94,-46.94,;43.09,-45.37,;44,-46.61,;43.37,-48.02,;41.84,-48.19,;41.22,-49.59,;39.69,-49.76,;42.13,-50.84,;45.53,-46.45,;46.15,-45.04,;46.44,-47.69,;47.97,-47.53,;48.59,-46.12,;50.12,-45.95,;50.74,-44.54,;52.27,-44.38,;52.9,-42.97,;54.43,-42.81,;51.99,-41.73,;48.88,-48.77,;48.25,-50.18,;50.41,-48.6,;51.32,-49.85,;50.69,-51.26,;51.6,-52.5,;50.97,-53.9,;51.87,-55.14,;53.41,-54.98,;54.03,-53.57,;53.13,-52.32,;52.85,-49.68,;53.76,-50.93,;53.47,-48.27,)|
Structure
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