| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50023017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212940 |
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| IC50 | 700±n/a nM |
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| Citation |  Manley, PW; Allanson, NM; Booth, RF; Buckle, PE; Kuzniar, EJ; Lad, N; Lai, SM; Lunt, DO; Tuffin, DP Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors. J Med Chem30:1588-95 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50023017 |
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| n/a |
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| Name | BDBM50023017 |
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| Synonyms: | CHEMBL41231 | ethyl 4-[2-(4-ethyloxycarbonylbenzyloxy)-1-(1H-1-imidazolylmethyl)ethoxymethyl]benzoate |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N2O6 |
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| Mol. Mass. | 466.5262 |
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| SMILES | CCOC(=O)c1ccc(COCC(Cn2ccnc2)OCc2ccc(cc2)C(=O)OCC)cc1 |
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| Structure | 
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