| Reaction Details |
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 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
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| Ligand | BDBM50462090 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1772702 (CHEMBL4229694) |
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| Ki | 440±n/a nM |
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| Citation |  Iyer, A; Xu, W; Reid, RC; Fairlie, DP Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem61:3253-3276 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mannan-binding lectin serine protease 2 |
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| Name: | Mannan-binding lectin serine protease 2 |
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| Synonyms: | 3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75689.43 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117891 |
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| Residue: | 686 |
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| Sequence: | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
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| BDBM50462090 |
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| n/a |
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| Name | BDBM50462090 |
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| Synonyms: | CHEMBL4242095 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N9O4S4 |
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| Mol. Mass. | 671.837 |
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| SMILES | CSc1sc(cc1S(=O)(=NS(=O)(=O)c1cccc(NC(N)=O)c1)c1cccc(c1)-c1c(C)cc(NC(N)=N)cc1N)C(N)=N |
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| Structure | 
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