| Reaction Details |
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 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 1 |
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| Ligand | BDBM50462102 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1772706 (CHEMBL4229698) |
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| IC50 | 40±n/a nM |
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| Citation |  Iyer, A; Xu, W; Reid, RC; Fairlie, DP Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem61:3253-3276 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mannan-binding lectin serine protease 1 |
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| Name: | Mannan-binding lectin serine protease 1 |
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| Synonyms: | 3.4.21.- | CRARF | CRARF1 | Complement factor MASP-3 | Complement-activating component of Ra-reactive factor | MASP-1 | MASP1 | MASP1_HUMAN | Mannan-binding lectin serine protease 1 | Mannan-binding lectin serine protease 1 heavy chain | Mannan-binding lectin serine protease 1 light chain | Mannose-binding lectin-associated serine protease 1 | Mannose-binding protein-associated serine protease | PRSS5 | Ra-reactive factor serine protease p100 | RaRF | Serine protease 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79230.21 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118013 |
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| Residue: | 699 |
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| Sequence: | MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL
GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL
HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET
LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW
YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
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| BDBM50462102 |
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| n/a |
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| Name | BDBM50462102 |
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| Synonyms: | CHEMBL4240381 |
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| Type | Small organic molecule |
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| Emp. Form. | C63H107N17O19S2 |
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| Mol. Mass. | 1470.756 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(O)=O |r| |
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| Structure | 
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