Reaction Details |
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Target | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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Ligand | BDBM2605 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1777052 (CHEMBL4234044) |
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IC50 | 30±n/a nM |
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Citation | Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg Med Chem26:4209-4224 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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Name: | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
Synonyms: | Glycogen synthase kinase-3 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 2105817 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Glycogen synthase kinase-3 beta |
Synonyms: | Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3 |
Type: | PROTEIN |
Mol. Mass.: | 46774.42 |
Organism: | Sus scrofa |
Description: | ChEMBL_939732 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
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Component 2 |
Name: | [Tau protein] kinase |
Synonyms: | GSK3A | Glycogen synthase kinase 3 alpha |
Type: | PROTEIN |
Mol. Mass.: | 51010.29 |
Organism: | Sus scrofa |
Description: | ChEMBL_117799 |
Residue: | 483 |
Sequence: | MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGV
GASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLP
PLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLT
NSS
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BDBM2605 |
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n/a |
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Name | BDBM2605 |
Synonyms: | (Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-indol-3-yl)-4-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}-2,5-dihydro-1H-pyrrole-2,5-dione |
Type | Small organic molecule |
Emp. Form. | C21H16N4O2 |
Mol. Mass. | 356.3773 |
SMILES | Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ncccc23)c2ccccc12 |t:4| |
Structure |
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