| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
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| Ligand | BDBM50463507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1778485 (CHEMBL4235477) |
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| Kd | 39±n/a nM |
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| Citation |  Hudson, L; Mui, J; Vázquez, S; Carvalho, DM; Williams, E; Jones, C; Bullock, AN; Hoelder, S Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. J Med Chem61:7261-7272 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1B |
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| Name: | Bone morphogenetic protein receptor type-1B |
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| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56939.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00238 |
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| Residue: | 502 |
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| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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| BDBM50463507 |
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| n/a |
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| Name | BDBM50463507 |
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| Synonyms: | CHEMBL4247751 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15N3O |
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| Mol. Mass. | 301.3419 |
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| SMILES | Cc1nc2ccc(c(C)c2c(=O)[nH]1)-c1ccnc2ccccc12 |
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| Structure | 
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