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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ||
| Ligand | BDBM50011036 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_78342 (CHEMBL691978) | ||
| Ki | 1.4±n/a nM | ||
| Citation |  Heathcock, CH; Hadley, CR; Rosen, T; Theisen, PD; Hecker, SJ Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin. J Med Chem30:1858-73 (1987) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | |||
| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ||
| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 96689.85 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Isolated rat liver microsomes were used as enzyme source. | ||
| Residue: | 887 | ||
| Sequence: |
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| BDBM50011036 | |||
| n/a | |||
| Name | BDBM50011036 | ||
| Synonyms: | (S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate | (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester | 2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester | 2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester((+)-compactin) | 2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(Compactin) | CHEMBL54440 | MEVASTATIN | cid_64715 | compactin | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H34O5 | ||
| Mol. Mass. | 390.5131 | ||
| SMILES | CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 |r,c:12,t:10| | ||
| Structure | 
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