| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50464474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1780729 (CHEMBL4252246) |
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| IC50 | 23±n/a nM |
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| Citation |  Faria, RX; Oliveira, FH; Salles, JP; Oliveira, AS; von Ranke, NL; Bello, ML; Rodrigues, CR; Castro, HC; Louvis, AR; Martins, DL; Ferreira, VF 1,4-Naphthoquinones potently inhibiting P2X7 receptor activity. Eur J Med Chem143:1361-1372 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | P2RX7_MOUSE | P2rx7 | P2x7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68405.16 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1473824 |
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| Residue: | 595 |
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| Sequence: | MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
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| BDBM50464474 |
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| n/a |
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| Name | BDBM50464474 |
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| Synonyms: | CHEMBL4281588 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10O3 |
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| Mol. Mass. | 250.2488 |
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| SMILES | OC1=C(C(=O)c2ccccc2C1=O)c1ccccc1 |t:1| |
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| Structure | 
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