Reaction Details |
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Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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Ligand | BDBM50464731 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1782193 (CHEMBL4253710) |
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IC50 | 1580±n/a nM |
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Citation | Jafari, B; Ospanov, M; Ejaz, SA; Yelibayeva, N; Khan, SU; Amjad, ST; Safarov, S; Abilov, ZA; Turmukhanova, MZ; Kalugin, SN; Ehlers, P; Lecka, J; Sévigny, J; Iqbal, J; Langer, P 2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study. Eur J Med Chem144:116-127 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alkaline phosphatase, tissue-nonspecific isozyme |
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Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
Type: | PROTEIN |
Mol. Mass.: | 57306.17 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1448917 |
Residue: | 524 |
Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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BDBM50464731 |
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n/a |
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Name | BDBM50464731 |
Synonyms: | CHEMBL4295150 |
Type | Small organic molecule |
Emp. Form. | C14H11F3N4O2S |
Mol. Mass. | 356.323 |
SMILES | CCOc1ccc(Nc2nn3c(nc(cc3=O)C(F)(F)F)s2)cc1 |
Structure |
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