| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (fumarate) |
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| Ligand | BDBM50056908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1791599 (CHEMBL4263518) |
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| IC50 | 73200±n/a nM |
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| Citation |  Chibli, LA; Schmidt, TJ; Nonato, MC; Calil, FA; Da Costa, FB Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. Eur J Med Chem157:852-866 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (fumarate) |
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| Name: | Dihydroorotate dehydrogenase (fumarate) |
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| Synonyms: | 1.3.98.1 | DHODH | Dihydroorotate dehydrogenase (fumarate) | Dihydroorotate oxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34659.43 |
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| Organism: | Leishmania major |
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| Description: | ChEMBL_118088 |
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| Residue: | 320 |
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| Sequence: | MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQ
ALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATE
KGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAE
ILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRR
CPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQ
TLDEFRGKVRTLDGTAESTR
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| BDBM50056908 |
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| n/a |
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| Name | BDBM50056908 |
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| Synonyms: | (1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-1,5-dihydroxy-cyclohexanecarboxylic acid | (1R,3R,4S,5R)-3,4-bis(3-(3,4-dihydroxyphenyl)acryloyloxy)-1,5-dihydroxycyclohexanecarboxylic acid | 3,4-di-O-caffeoylquinicacid | 4,5-di-O-caffeoylquinic acid | CHEMBL177126 | NSC-649410 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24O12 |
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| Mol. Mass. | 516.4509 |
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| SMILES | O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r| |
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| Structure | 
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