| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor; alpha9/alpha10 |
|---|
| Ligand | BDBM50466608 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1793438 (CHEMBL4265357) |
|---|
| IC50 | 6.6±n/a nM |
|---|
| Citation |  Bavo, F; Pucci, S; Fasoli, F; Lammi, C; Moretti, M; Mucchietto, V; Lattuada, D; Viani, P; De Palma, C; Budriesi, R; Corradini, I; Dowell, C; McIntosh, JM; Clementi, F; Bolchi, C; Gotti, C; Pallavicini, M Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan. J Med Chem61:10531-10544 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor; alpha9/alpha10 |
|---|
| Name: | Neuronal acetylcholine receptor; alpha9/alpha10 |
|---|
| Synonyms: | Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit | Neuronal acetylcholine receptor subunit alpha-10/alpha-9 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 2150170 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit alpha-9 |
|---|
| Synonyms: | ACHA9_HUMAN | CHRNA9 | NACHR alpha-9 | NACHRA9 | Neuronal acetylcholine receptor protein alpha-9 subunit | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha-9 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 54806.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_306102 |
|---|
| Residue: | 479 |
|---|
| Sequence: | MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
|
|
|
|---|
| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit alpha-10 |
|---|
| Synonyms: | ACH10_HUMAN | CHRNA10 | NACHRA10 | Neuronal acetylcholine receptor protein alpha-10 subunit |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49714.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | EBI_12740 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
RLARVMDRFFLAIFFSMALVMSLLVLVQAL
|
|
|
|---|
| BDBM50466608 |
|---|
| n/a |
|---|
| Name | BDBM50466608 |
|---|
| Synonyms: | CHEMBL4285772 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H42INO |
|---|
| Mol. Mass. | 535.5437 |
|---|
| SMILES | [I-].CC[N+](CC)(CC)CCCCCCCCOc1ccc(\C=C\c2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
