Reaction Details |
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Target | Macrophage metalloelastase |
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Ligand | BDBM50466696 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1793824 (CHEMBL4265743) |
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IC50 | 41±n/a nM |
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Citation | Cuffaro, D; Camodeca, C; D'Andrea, F; Piragine, E; Testai, L; Calderone, V; Orlandini, E; Nuti, E; Rossello, A Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates. Bioorg Med Chem26:5804-5815 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage metalloelastase |
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Name: | Macrophage metalloelastase |
Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
Type: | Enzyme |
Mol. Mass.: | 54012.99 |
Organism: | Homo sapiens (Human) |
Description: | P39900 |
Residue: | 470 |
Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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BDBM50466696 |
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n/a |
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Name | BDBM50466696 |
Synonyms: | CHEMBL4286237 |
Type | Small organic molecule |
Emp. Form. | C26H34N2O9S |
Mol. Mass. | 550.621 |
SMILES | CO[C@@H]1O[C@H](CN([C@H](C(C)C)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccccc2)[C@@H](O)[C@H](O)[C@H]1NC(C)=O |r| |
Structure |
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