| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-9 |
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| Ligand | BDBM50466706 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1793825 (CHEMBL4265744) |
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| IC50 | 32±n/a nM |
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| Citation |  Cuffaro, D; Camodeca, C; D'Andrea, F; Piragine, E; Testai, L; Calderone, V; Orlandini, E; Nuti, E; Rossello, A Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates. Bioorg Med Chem26:5804-5815 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-9 |
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| Name: | Matrix metalloproteinase-9 |
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| Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
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| Type: | Enzyme |
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| Mol. Mass.: | 78452.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14780 |
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| Residue: | 707 |
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| Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
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| BDBM50466706 |
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| n/a |
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| Name | BDBM50466706 |
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| Synonyms: | CHEMBL4291027 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H43N3O12S2 |
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| Mol. Mass. | 737.837 |
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| SMILES | CO[C@@H]1O[C@H](CNC(=S)NCCN([C@H](C(C)C)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccccc2)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O |r| |
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| Structure | 
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