| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 2 |
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| Ligand | BDBM182847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1793892 (CHEMBL4265811) |
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| IC50 | 102850±n/a nM |
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| Citation |  Shibuya, K; Kawamine, K; Ozaki, C; Ohgiya, T; Edano, T; Yoshinaka, Y; Tsunenari, Y Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor. J Med Chem61:10635-10650 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 2 |
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| Name: | Sterol O-acyltransferase 2 |
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| Synonyms: | ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 59912.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75908 |
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| Residue: | 522 |
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| Sequence: | MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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| BDBM182847 |
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| n/a |
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| Name | BDBM182847 |
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| Synonyms: | US9149492, K-604 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N6OS3 |
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| Mol. Mass. | 502.719 |
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| SMILES | CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3[nH]2)CC1 |
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| Structure | 
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