| Reaction Details |
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 | Report a problem with these data |
| Target | Targeting protein for Xklp2 |
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| Ligand | BDBM50315769 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1794205 (CHEMBL4266322) |
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| Ki | 490±n/a nM |
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| Citation |  Borisa, AC; Bhatt, HG A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies. Eur J Med Chem140:1-19 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Targeting protein for Xklp2 |
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| Name: | Targeting protein for Xklp2 |
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| Synonyms: | C20orf1 | C20orf2 | DIL-2 | DIL2 | Differentially expressed in cancerous and non-cancerous lung cells 2 | HCA519 | Hepatocellular carcinoma-associated antigen 519 | Hepatocellular carcinoma-associated antigen 90 | Protein fls353 | Restricted expression proliferation-associated protein 100 | TPX2 | TPX2_HUMAN | Targeting protein for Xklp2 | p100 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85686.81 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117017 |
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| Residue: | 747 |
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| Sequence: | MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTP
LRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRR
SLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTA
EKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLAL
AGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKG
CTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSV
TKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK
KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP
ITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSF
DSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRR
GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF
QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK
YQGLEIKSSDQPLTVPVSPKFSTRFHC
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| BDBM50315769 |
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| n/a |
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| Name | BDBM50315769 |
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| Synonyms: | 3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea | 4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | CHEMBL1090479 | GSK-1070916 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N7O |
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| Mol. Mass. | 507.6293 |
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| SMILES | CCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN(C)C)c1 |
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| Structure | 
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