| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 1 |
|---|
| Ligand | BDBM50467537 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1796416 (CHEMBL4268533) |
|---|
| IC50 | 86±n/a nM |
|---|
| Citation |  Diedrich, D; Stenzel, K; Hesping, E; Antonova-Koch, Y; Gebru, T; Duffy, S; Fisher, G; Schöler, A; Meister, S; Kurz, T; Avery, VM; Winzeler, EA; Held, J; Andrews, KT; Hansen, FK One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. Eur J Med Chem158:801-813 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 1 |
|---|
| Name: | Histone deacetylase 1 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55090.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13547 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
|---|
| BDBM50467537 |
|---|
| n/a |
|---|
| Name | BDBM50467537 |
|---|
| Synonyms: | CHEMBL4292530 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H33N3O4 |
|---|
| Mol. Mass. | 451.5579 |
|---|
| SMILES | CC(C)c1ccc(cc1)C(=O)N(CC(=O)NC1CCCCC1)Cc1ccc(cc1)C(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
