| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50467538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1796416 (CHEMBL4268533) |
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| IC50 | 552±n/a nM |
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| Citation |  Diedrich, D; Stenzel, K; Hesping, E; Antonova-Koch, Y; Gebru, T; Duffy, S; Fisher, G; Schöler, A; Meister, S; Kurz, T; Avery, VM; Winzeler, EA; Held, J; Andrews, KT; Hansen, FK One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. Eur J Med Chem158:801-813 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50467538 |
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| n/a |
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| Name | BDBM50467538 |
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| Synonyms: | CHEMBL4280840 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N3O4 |
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| Mol. Mass. | 459.5369 |
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| SMILES | ONC(=O)c1ccc(CN(CC(=O)NC2CCCCC2)C(=O)c2cccc3ccccc23)cc1 |
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| Structure | 
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