Reaction Details |
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Target | Heme oxygenase 1 |
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Ligand | BDBM50467686 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1796598 (CHEMBL4268715) |
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IC50 | 920±n/a nM |
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Citation | Sorrenti, V; Pittalą, V; Romeo, G; Amata, E; Dichiara, M; Marrazzo, A; Turnaturi, R; Prezzavento, O; Barbagallo, I; Vanella, L; Rescifina, A; Floresta, G; Tibullo, D; Di Raimondo, F; Intagliata, S; Salerno, L Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. Eur J Med Chem158:937-950 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heme oxygenase 1 |
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Name: | Heme oxygenase 1 |
Synonyms: | HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1 |
Type: | Enzyme |
Mol. Mass.: | 33005.15 |
Organism: | Rattus norvegicus (rat) |
Description: | HO-1 obtained from rat spleen was used in enzyme assays. |
Residue: | 289 |
Sequence: | MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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BDBM50467686 |
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n/a |
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Name | BDBM50467686 |
Synonyms: | CHEMBL4289670 |
Type | Small organic molecule |
Emp. Form. | C30H28BrN7O2 |
Mol. Mass. | 598.493 |
SMILES | Cc1ccc(NC(=O)c2ccc(OCCCCn3ccnc3)c(Br)c2)cc1Nc1nccc(n1)-c1cccnc1 |
Structure |
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